个人简介

吕优优，男，中共党员，博士。2021年12月引入BG电子为专任教师，研究方向为功能性乳品与益生乳酸菌工程。目前作为负责人主持“国家自然科学基金”“湖北省自然科学基金”“中央高校自主科技创新基金”“企业横向课题”等多个科研项目，作为骨干参与国家重点研发计划2项。已在《Theranostics》《Journal of Agricultural and Food Chemistry》（封面）《Food Chemistry》《Molecular Nutrition & Food Research》《Food & Function》等权威期刊发表研究论文30余篇，包括26篇SCI，一作&通讯10篇；荣获“山东省高等学校科学技术一等奖”1次；申请专利3项，已公布3项（含授权1项）；参编专著4部（含出版2部）；担任《Frontiers in Microbiology》(TOP期刊)评审编辑；《Food& Function》(TOP期刊)、《Journal of the Science of Food and Agriculture》(TOP期刊)、《Food Bioscience》、《Frontiers in Nutrition》、《Fermentation》、《Microorganisms》等SCI及同水平国际学术期刊审稿人。

教育经历

2021年6月毕业于中国海洋大学, 获食品科学博士学位

工作经历

2021.12-至今, 华中农业大学, BG电子, 讲师

研究领域

1. 致力于有益微生物资源发掘与利用
2. 致力于有益乳酸菌相关代谢调控机制研究
3. 致力于乳品相关功能活性成分机制研究

科研项目

1. 国家自然科学基金青年基金，项目号：32202061，2023.01-2025.12，主持。
2. 湖北省自然科学基金青年基金，项目号：2022CFB763，2022.06-2024.06，主持。
3. 中央高校自主科技创新基金, 项目号：2662022SPQD001，2022.01-2024.12, 主持。
4. 企业横向课题，项目号：0220230048，2023.04-2024.03, 主持。
5. 国家重点研发计划，“乳酸菌或蛋白酶水解生产特定功能乳制品产品研究与应用示范”，2576万元，项目号：2018YFC1604302，2018.12-2021.12，结题，骨干。
6. 国家重点研发计划，“恶性肿瘤姑息治疗和护理关键技术研究”，50万元，项目号：2017YFC1309200，2017.07-2020.12，结题，骨干。
7. 国家自然科学基金青年基金, “乳脂球膜组成对乳脂结构的影响及机理研究”, 项目号：31801500, 2019.01-2021.12, 结题，参与。
8. 国家自然科学基金面上项目, 项目号：32272288, 2023.01-2026.12, 在研，参与。
9. 国家自然科学基金面上项目, 项目号：32272469, 2023.01-2026.12, 在研，参与。

成果奖励

【发表论文】
1. Yalin Zhang, Youyou Lu*, Fusheng Chen*. Relationship between physicochemical properties and microbial structural distribution of Chinese-style and Salami fermented sausages. Food Bioscience,2023, 53:102583
2. Yeting Wu#, Youyou Lu#, Yuhao Huang, Junyu Wang, Siyue Li, Mengyao Xu, Hong Lin, and Zhenxing Li*. Comparative analysis of glycosylation affecting sensitization by regulating the cross-Reactivity of parvalbumins in turbot (Scophthalmus maximus), conger eel (Conger myriaster) and sea bass (Micropterus salmoides). Journal of Agricultural and Food Chemistry, 2022, 70(34):10611-10619（封面）
3. Youyou Lu, Xi Liang, Yeting Wu, Ruiqi Wang, Tongjie Liu, Huaxi Yi, Zhuang Yu, Zhe Zhang, Pimin Gong* & Lanwei Zhang*. Bifidobacterium animalis sup F1-7 acts as an effective activator to regulate immune response via Casepase-3 and Bak of FAS/CD95 pathway. Probiotics and Antimicrobial Proteins, 2022, Doi: 10.1007/s12602-022-09975-9
4. Youyou Lu, Zhuang Yu, Zhe Zhang, Xi Liang, Pimin Gong, Huaxi Yi, Liuqing Yang, Tongjie Liu, Hanping Shi*, Lanwei Zhang*. Bifidobacterium animalis F1-7 in combination with konjac glucomannan improves constipation in mice via humoral transport. Food & Function, 2021, 12(2):791-801
5. Youyou Lu, Zhe Zhang, Lingjun Tong, Xiaohong Zhou, Xi Liang, Huaxi Yi1, Pimin Gong, Tongjie Liu, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Mechanisms underlying the promotion of 5-hydroxytryptamine secretion in enterochromaffin cells of constipation mice by Bifidobacterium and Lactobacillus. Neurogastroenterology and Motility, 2021, 33: e14082
6. Youyou Lu#, Junxue Zhang#, Xiaohong Zhou, Meiyu Guan, Zhe Zhang, Xi Liang, Lingjun Tong, Huaxi Yi, Pimin Gong, Lu Bai, Hui Zhou, Tongjie Liu*, Lanwei Zhang*. The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish. Neurogastroenterology and Motility, 2021, 33: e14196
7. Youyou Lu#, Junxue Zhang#, Zhe Zhang, Xi Liang, Tongjie Liu, Huaxi Yi, Pimin Gong, Lingli Wang, Wenjun Yang, Xinyi Zhang, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release. Nutrition, 2021, 84:111112
8. Youyou Lu, Zhe Zhang, Xi Liang, Yujie Chen, Junxue Zhang, Huaxi Yi, Tongjie Liu, Liuqing Yang, Hanping Shi*, Lanwei Zhang*. Study of gastrointestinal tract viability and motility via modulation of serotonin in a zebrafish model by probiotics. Food & Function, 2019, 10(11):7416-7425
9. Youyou Lu, Junxue Zhang, Huaxi Yi, Zhe Zhang, Lanwei Zhang*. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model. Food & Function, 2019, 10(4):2075-2082
10. Youyou Lu, Nana Wang, Jiao He, Yanfang Li, Xiaoning Gao, Lili Huang*, Xia Yan*. Expression and characterization of a novel chitinase with antifungal activity from a rare actinomycete, Saccharothrix yanglingensis Hhs.015. Protein Expression and Purification, 2018,143:45-51
11. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Guanzhi Chen, Yan Chen, Zhenxing Li*. Glycosylation reduces the allergenicity of turbot (Scophthalmus maximus) parvalbumin by regulating digestibility, cellular mediators release and Th1/Th2 immunobalance. Food Chemistry, 2022,382:132574
12. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Mengyao Xu, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Fish allergens of turbot (Scophthalmus maximus) parvalbumin triggers food allergy via inducing maturation of bone marrow derived dendritic cell and driving Th2 immune response. Food & Function, 2022,13:4194-4204
13. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Xuewen Dang, Yujie Jing, Zhaocheng Meng, Xiangchen Wang*, Zhenxing Li*. Insight analysis of the cross sensitisation of multiple fish parvalbumins via the Th1/Th2 immunological balance and cytokine release from the perspective of safe consumption of fish, Food Quality and Safety, 2022, Doi:10.1093/fqsafe/fyac056
14. Xi Liang, Youyou Lv, Zhe Zhang, Huaxi Yi, Tongjie Liu, Rui Li, Zhuang Yu, Lanwei Zhang*. Study on intestinal survival and cholesterol metabolism of probiotics. LWT-Food Science and Technology, 2020, 124: 109132
15. Xi Liang, Zhe Zhang, Youyou Lv, Haiyan Lu, Tongjie Liu, Huaxi Yi, Maozhen Zhao, Lanwei Zhang *，Pimin Gong*. Krill oil combined with Bifidobacterium animalis subsp. lactis F1-7 alleviates the atherosclerosis of ApoE-/- mice. Foods, 2021, 10, 2374
16. Zhe Zhang, Xi Liang, Youyou Lv, Huaxi Yi, Yujie Chen, Lu Bai, Hui Zhou, Tongjie Liu, Rui Li, Lanwei Zhang*. Evaluation of probiotics for improving and regulation metabolism relevant to type 2 diabetes in vitro. Journal of Functional Foods, 2020, 64:103664
17. Xi Liang, Zhe Zhang, Youyou Lv, Linjun Tong, Tongjie Liu, Huaxi Yi, Xiaohong Zhou, Zhuang Yu, Xiaoying Tian, Qingyu Cui, Jiebing Yang, Pimin Gong, Lanwei Zhang*. Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis. Nutrition, 2020, 79:110941
18. Yeting Wu, Hong Lin, Youyou Lu, Yuhao Huang, Binaka Prabashini Dasanayaka, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL-2H3 cell and mouse model. European Food Research and Technology, 2021,1-16
19. Lingjun Tong, Haining Hao, Zhe Zhang, Youyou Lv, Xi Liang, Qiqi Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Fangfang Cao, Giorgia Pastorin, Chuen Neng Lee, Xiaoyuan Chen, Jiong-Wei Wang*, Huaxi Yi*. Milk-derived extracellular vesicles alleviate ulcerative colitis byregulating the gut immunity and reshaping the gut microbiota. Theranostics, 2021, 11(17): 8570-8586
20. Zhe Zhang, Xi Liang, Lingjun Tong, Youyou Lv, Huaxi Yi, Pimin Gong, XiaoyingTian, Qingyu Cui, Tongjie Liua*, Lanwei Zhang*. Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice. Journal of Ethnopharmacology, 2021, 273:113963
21. Xi Liang, Zhe Zhang, Xiaohong Zhou, Youyou Lu, Rui Li, Zhuang Yu, Lingjun Tong, Pimin Gong, Huaxi Yi, Tongjie Liu*, Lanwei Zhang*. Probiotics improved hyperlipidemia in mice induced by a high cholesterol diet via downregulating FXR. Food & Function, 2020, 11(11):9903-9911
22. Zhe Zhang, Hui Zhou, Lu Bai, Youyou Lv, Huaxi Yi, Lanwei Zhang*, Rui Li*. Protective effects of probiotics on acute alcohol-induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-α response reduction. Journal of Functional Foods, 2019, 59:234-241
23. Lingjun Tong, Haining Hao, Xinyi Zhang, Zhe Zhang, Youyou Lv, Lanwei Zhang, Huaxi Yi*. Oral administration of bovine milk-derived extracellular vesicles alters the gut microbiota and enhances intestinal immunity in mice. Molecular Nutrition & Food Research, 2020, 64(8):1901251（封面）
24. Zhe Zhang#, Hui Zhou#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in mice. British Journal of Nutrition, 2020, 28:1-11
25. Zhe Zhang#, Hui Zhou#, Xiaohong Zhou, Jize Sun, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 ameliorates markers of non-alcoholic fatty liver and alters expression of genes within the intestinal bile acid pathway. British Journal of Nutrition, 2021, 125(5):521-529
26. Zhe Zhang#, Lu Bai#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Huaxi Yi, Hui Zhou, Tongjie Liu*, Pimin Gong, Jize Sun*, Lanwei Zhang*. Potential probiotics Lactobacillus casei K11 combined with plant extracts reduce markers of type 2 diabetes mellitus in mice. Journal of Applied Microbiology, 2021, 131, 1970-1982
【申报专利】
1. 张兰威，吕优优，公丕民，刘同杰，易华西，张喆，梁曦。一株促肠蠕动动物双歧杆菌亚种F1-7及应用。（授权号CN 113564067 B）
2. 公丕民，吕优优，张兰威，刘同杰，易华西，张喆，梁曦。一株副干酪乳杆菌X11及其组合物便秘复合制剂及乳制品。（公布号CN 112694989 A）
3. 张兰威，吕优优，公丕民，刘同杰，易华西，张喆，梁曦。一株动物双歧杆菌F1-7、组合物、粪便干结复合制剂及果乳制品。（公布号CN 113186113 A）
【已出版的参编专著】
1. 《肿瘤微生态学》/石汉平等主编.北京:科学出版社，2021.06，ISBN 9787030691347
2. 《肿瘤代谢学》/石汉平等主编.北京:科学出版社，2023.03，ISBN 9787030737373
【荣誉奖励】 1. 中国食品科学技术学会第一届“飞鹤杯”乳制品创新竞赛优秀作品奖（迟晨鸣等），共同指导教师，2022
2. 湖北省第五届大学生酸奶DIY创新竞赛省级前4强（罗依婷等），共同指导教师，2022；
3. 华中农业大学第五届大学生酸奶DIY创新竞赛十佳作品奖（苏雯静等），独立指导教师，2022；
4. 华中农业大学第五届大学生酸奶DIY创新竞赛十佳作品奖（袁懿然等），独立指导教师，2022；
5. 华中农业大学第五届大学生酸奶DIY创新竞赛十佳作品奖（窦化鹏等），独立指导教师，2022；
6. 华中农业大学第五届大学生酸奶DIY创新竞赛优秀作品奖（迟红婷等），独立指导教师，2022；
7. “华中农业大学暑期社会实践活动优秀指导教师”，2022；
8. “第十六届益生菌与健康国际研讨会优秀论文奖”，2021；
9. “山东省高等学校科学技术奖一等奖”—（益生乳酸菌定向筛选及其高活性产品开发的关键技术），2020；
【学术兼职】
受邀担任《Frontiers in Microbiology》(TOP期刊)评审编辑；《Food& Function》(TOP期刊)、《Journal of the Science of Food and Agriculture》(TOP期刊)、《Food Bioscience》、《Frontiers in Nutrition》、《Fermentation》、《Microorganisms》等SCI及同水平国际学术期刊审稿人。

师资力量